新藥研發

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Oncology
A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens, including one platinum-based chemotherapy regimen.
Lee YC. et al, Molecular and Clinical Oncology. DOI: 10.3892/mco.2015.642
Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles
Kumar VB. et al, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. DOI: 10.1016/j.mrfmmm.2010.12.009
Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways.
Chiang PC. et al, Biochemical Pharmacology. DOI: 10.1016/j.bcp.2009.08.022
Hypermethylation of CCND2 in lung and breast cancer is a potential biomarker and drug target.
Hung CS. et al, International Journal of Molecular Sciences. DOI: 10.3390/ijms19103096
Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells.
Ho CL. et al, Biomedicine and Pharmacotherapy. DOI: 10.1016/j.biopha.2014.09.008
Antroquinonol targets FAK-signaling pathway suppressed cell migration, invasion, and tumor growth of C6 glioma.
Thiyagarajan V. et al, PLoS ONE. DOI: 10.1371/journal.pone.0141285
Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions.
Lee WT. et al, Food and Chemical Toxicology. DOI: 10.1016/j.fct.2015.01.012
Antroquinonol, a ubiquinone derivative from the mushroom Antrodia camphorata, inhibits colon cancer stem cell-like properties: Insights into the molecular mechanism and inhibitory targets.
Lin HC. et al, Journal of agricultural and food chemistry. DOI: 10.1021/acs.jafc.6b04101
Neurodegenerative Disease
Antroquinonol lowers brain amyloid-β levels and improves spatial learning and memory in a transgenic mouse model of Alzheimer's disease.
Chang WH. et al, Scientific Reports. DOI: 10.1038/srep15067
Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD): A new avenue for modifying progression of AD pathophysiology.
Francesca F. et al, Brain, Behavior, & Immunity - Health. DOI: 10.1016/j.bbih.2022.100435